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Propionibacterium acnes MLST Databases

This site uses two linked databases powered by the BIGSdb genomics platform. The sequence definition database contains allele sequence and MLST profile definitions whereas the isolate database contains provenance and epidemiological information. Further details about BIGSdb can be found in Jolley & Maiden 2010, BMC Bioinformatics 11:595.

The Propionibacterium acnes MLST scheme has now been updated to six housekeeping genes and two putative virulence genes. The expanded scheme gives high resolution typing and phylogenetic inferences that are concordant with phylogenomic analyses. This updated version is described in McDowell et al. An Expanded Multilocus Sequence Typing Scheme for Propionibacterium acnes: Investigation of 'Pathogenic', 'Commensal' and Antibiotic Resistant Strains. PLoS ONE 7(7):e41480. doi:10.1371/journal.pone.0041480. It was developed by Andrew McDowell and Emma Barnard (Centre for Infection & Immunity, Queen's University, Belfast, UK).

The original seven gene scheme is described in McDowell et al. A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens. Microbiology 2011. 157:1990-2003. It was originally developed by Anna Gao and Chris Dowson (University of Warwick, UK) in collaboration with Andrew McDowell and Sheila Patrick (Centre for Infection & Immunity, Queens University, Belfast, UK).

Database curated by Anna Gao and Andrew McDowell.

Citing the database

The preferred format for citing this website in publications is:

This publication made use of the Propionibacterium acnes MLST website (http://pubmlst.org/ pacnes/) developed by Keith Jolley and sited at the University of Oxford (Jolley & Maiden 2010, BMC Bioinformatics, 11:595). The development of this site has been funded by the Wellcome Trust.