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Wolbachia MLST genes

The Wolbachia pipientis MLST scheme uses fragments of the following five conserved genes:

gatB:aspartyl/glutamyl-tRNA(Gln) amidotransferase, subunit B (wMel locus WD_0146)
coxA:cytochrome c oxidase, subunit I (WD_0301)
hcpA:conserved hypothetical protein, NCBI COG0217 (WD_0484)
ftsZ:cell division protein (WD_0723)
fbpA:fructose-bisphosphate aldolase (WD_1238)

These genes were chosen from an initial collection of 46 loci on the basis of the following features:

  1. presence throughout the sequenced Rickettsiales order
  2. a single copy within the wMel genome
  3. a wide spatial distribution in the wMel genome
  4. evidence of strong stabilizing selection within Wolbachia (average Ka/Ks<<1).

These criteria conform to the standard loci requirements for an MLST system.

Citing the database

The preferred format for citing this website in publications is:

This publication made use of the MLST website (https://pubmlst.org/ wolbachia/) sited at the University of Oxford (Jolley & Maiden 2010, BMC Bioinformatics, 11:593). The development and maintenance of this site has been funded by the Wellcome Trust.

Citation for use of the Wolbachia MLST system and database is Baldo et al. 2006, Appl Environ Microbiol 72:7098-7110. Development and curation of the Wolbachia MLST system has been supported by funds from the US National Science Foundation to Jack Werren as part of community outreach activities.


Sequence database
Sequences: 3,673
Profiles (MLST): 576
Last updated: 2020-02-24

Isolate database
Isolates: 2,019
Last updated: 2020-02-24