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NucleBact - Nuclease Bacteriocin Database

Nuclease bacteriocins are antimicrobial proteins produced by bacteria that are capable of directly inhibiting closely related bacterial strains. In bacteriocin producing strains, co-expression of the dedicated immunity gene, downstream of the bacteriocin prevents self-inhibition. Nuclease bacteriocins have become drug candidates for narrow spectrum antibiotics, anti-cancer drugs and food preservatives.

NucleBact allows the phylogenetic analysis of nuclease bacteriocins and immunity sequences along with the prediction of bacteriocin susceptibility among γ-proteobacteria. Nuclease bacteriocins (BCIN) and immunity sequences (IMM) have been uploaded into the NucleBact database using the nuclease bacteriocin pipeline developed by Sharp et al. 2017, PLoS Comput Biol 13:e1005652.

This site uses two linked databases powered by the BIGSdb genomics platform. The sequence definition database contains allele sequence and MLST profile definitions whereas the isolate database contains provenance and epidemiological information. Further details about BIGSdb can be found in Jolley & Maiden 2010, BMC Bioinformatics 11:595.

Citing the database

The preferred format for citing this website in publications is:

This publication made use of the PubMLST Nuclebact database (https://pubmlst.org/ nuclebact/) sited at the University of Oxford (Jolley et al. Wellcome Open Res 2018, 3:124 [version 1; referees: 2 approved]). The development of this site has been funded by the Wellcome Trust.