Neisseria PubMLST Curators
Neisseria genomes hosted on PubMLST are annotated with their exact alleleic variant at >1600 loci. Ultimately, we aim to cover the entire Neisseria pan-genome using this gene-by-gene approach. Genome annotation has, in the past, involved individuals or small groups annotating the entire genome based on sequence similarity to existing records. This can lead to the propagation of errors in nomenclature related to perceived function.
We would like to engage the entire community in the annotation process. This involves the initial identification and ongoing oversight of linking coding sequences to function. Every locus defined in the database has a descriptive record that can contain details of the biochemical pathway that its product is a part of and links to the primary literature. If you have in-depth knowledge of a specialized part of Neisseria biology and would be willing to assist in this annotation process we would like to hear from you.
Various loci are currently being curated by specific curators from Oxford and external research groups. These are listed below.
- Antibiotic resistance loci; penA, gyrA and rpoB - Eva Hong (Institut Pasteur, Paris, France)
- Factor H-binding protein - Carina Brehony (University of Oxford, UK), Rolando Pajon (CHORI, USA), Eva Hong (Institut Pasteur, Paris, France)
- FetA variable regions - Ian Feavers (NIBSC, UK)
- LOS biosynthesis - Charlene Kahler (University of Western Australia, Australia), Arie van der Ende (Academic Medical Center, Amsterdam, The Netherlands), Peter van der Ley (Institute for Translational Vaccinology, The Netherlands)
- Maf loci - Anne Jamet (Institut Necker Enfants-Malades, INSERM, Paris, France)
- MLST loci - Keith Jolley and Odile Harrison (University of Oxford, UK)
- NadA - Stefania Bambini (Novartis Vaccines, Siena, Italy)
- Neisserial heparin binding antigen, NHBA (Alessandro Muzzi, Novartis Vaccines, Siena, Italy)
- NEIS2075 (adhesin complex protein) - Myron Christodoulides (University of Southampton, UK)
- NEIS1533 (histidine-binding periplasmic protein) - Myron Christodoulides (University of Southampton, UK)
- pilE/pilS - Rachel Exley (University of Oxford, UK), Ellen Aho (Concordia College, MN, USA)
- pilT/pilU - Alyson Hockenberry (University of Arizona, AZ, USA)
- PorA variable regions - Keith Jolley (University of Oxford, UK)
- porB - Heike Claus (University of Würzburg, Germany)
- rplF - Eleanor Watkins and Kanny Diallo (University of Oxford, UK)
- sRNA - Yvonne Pannekoek (Academic Medical Center, Amsterdam, The Netherlands)